The Interaction of Polyglutamine Peptides with Lipid Membranes Is Regulated by Flanking Sequences Associated with Huntingtin

Huntington disease (HD) is caused by an expanded polyglutamine (poly(Q)) repeat near the N terminus of the huntingtin (htt) protein. Expanded poly(Q) facilitates formation of htt aggregates, eventually leading to deposition of cytoplasmic and intranuclear inclusion bodies containing htt. Flanking se...

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Bibliographic Details
Main Authors: Burke, Kathleen A., Kauffman, Karlina J., Umbaugh, C. Samuel, Frey, Shelli L., Legleiter, Justin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663520/
https://ncbi.nlm.nih.gov/pubmed/23572526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446237
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