Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43)

Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is a pathological signature of amyotrophic lateral sclerosis (ALS). Although accumulating evidence suggests the involvement of RNA recognition motifs (RRMs) in TDP-43 proteinopathy, it remains unclear how native TDP-43 is converted to pathoge...

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Autori principali: Shodai, Akemi, Morimura, Toshifumi, Ido, Akemi, Uchida, Tsukasa, Ayaki, Takashi, Takahashi, Rina, Kitazawa, Soichiro, Suzuki, Sakura, Shirouzu, Mikako, Kigawa, Takanori, Muto, Yutaka, Yokoyama, Shigeyuki, Takahashi, Ryosuke, Kitahara, Ryo, Ito, Hidefumi, Fujiwara, Noriko, Urushitani, Makoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663511/
https://ncbi.nlm.nih.gov/pubmed/23558684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451849
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