Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals

Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is implicated in the pathogenesis of sporadic and certain familial forms of amyotrophic lateral sclerosis (ALS), suggesting elimination of TDP-43 aggregates as a possible therapeutic strategy. Here we generated and investigated a single-chain...

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Publicado en:Sci Rep
Main Authors: Tamaki, Yoshitaka, Shodai, Akemi, Morimura, Toshifumi, Hikiami, Ryota, Minamiyama, Sumio, Ayaki, Takashi, Tooyama, Ikuo, Furukawa, Yoshiaki, Takahashi, Ryosuke, Urushitani, Makoto
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902603/
https://ncbi.nlm.nih.gov/pubmed/29662239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24463-3
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