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Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.

Accumulating evidence suggests that pathogenic TAR DNA-binding protein (TDP)-43 fragments contain a partial RNA-recognition motif domain 2 (RRM2) in amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration. However, the molecular basis for how this domain links to the conformation and f...

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Autors principals: Akemi Shodai, Akemi Ido, Noriko Fujiwara, Takashi Ayaki, Toshifumi Morimura, Miki Oono, Tsukasa Uchida, Ryosuke Takahashi, Hidefumi Ito, Makoto Urushitani
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2012-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC3530536?pdf=render
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