Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43

Accumulating evidence suggests that pathogenic TAR DNA-binding protein (TDP)-43 fragments contain a partial RNA-recognition motif domain 2 (RRM2) in amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration. However, the molecular basis for how this domain links to the conformation and f...

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Detalhes bibliográficos
Main Authors: Shodai, Akemi, Ido, Akemi, Fujiwara, Noriko, Ayaki, Takashi, Morimura, Toshifumi, Oono, Miki, Uchida, Tsukasa, Takahashi, Ryosuke, Ito, Hidefumi, Urushitani, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530536/
https://ncbi.nlm.nih.gov/pubmed/23300771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052776
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