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The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor
T-cell receptor (TCR) triggering results in a cascade of intracellular tyrosine phosphorylation events that ultimately leads to T-cell activation. It is dependent on changes in the relative activities of membrane-associated tyrosine kinases and phosphatases near the engaged TCR. CD45 and CD148 are t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663424/ https://ncbi.nlm.nih.gov/pubmed/23580664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-442251 |
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