Initiation of T cell signaling by CD45 segregation at ‘close-contacts’

It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell receptor (TCR) triggering, but how segregation would occur and whether it can initiate signaling is unclear. Using structural and biophysical analysis we show that the extracellular region o...

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Bibliographic Details
Published in:Nat Immunol
Main Authors: Chang, Veronica T, Fernandes, Ricardo A, Ganzinger, Kristina A, Lee, Steven F, Siebold, Christian, McColl, James, Jönsson, Peter, Palayret, Matthieu, Harlos, Karl, Coles, Charlotte H, Jones, E Yvonne, Lui, Yuan, Huang, Elizabeth, Gilbert, Robert J C, Klenerman, David, Aricescu, A Radu, Davis, Simon J
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839504/
https://ncbi.nlm.nih.gov/pubmed/26998761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3392
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