Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1...

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Main Authors: Hyter, Stephen, Coleman, Daniel J., Ganguli-Indra, Gitali, Merrill, Gary F., Ma, Steven, Yanagisawa, Masashi, Indra, Arup K.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663331/
https://ncbi.nlm.nih.gov/pubmed/23279852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12063
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