DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism

Advanced age is one of the most important risk factors for osteoporosis. Accumulation of oxidative DNA damage has been proposed to contribute to age-related deregulation of osteoblastic and osteoclastic cells. ERCC1 (Excision Repair Cross Complementary group 1)-XPF (Xeroderma Pigmentosum Group F) is...

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Bibliografiske detaljer
Main Authors: Chen, Qian, Liu, Kai, Robinson, Andria R., Clauson, Cheryl L., Blair, Harry C., Robbins, Paul D., Niedernhofer, Laura J., Ouyang, Hongjiao
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662975/
https://ncbi.nlm.nih.gov/pubmed/23281008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1851
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