NF-κB inhibition delays DNA damage–induced senescence and aging in mice

The accumulation of cellular damage, including DNA damage, is thought to contribute to aging-related degenerative changes, but how damage drives aging is unknown. XFE progeroid syndrome is a disease of accelerated aging caused by a defect in DNA repair. NF-κB, a transcription factor activated by cel...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Tilstra, Jeremy S., Robinson, Andria R., Wang, Jin, Gregg, Siobhán Q., Clauson, Cheryl L., Reay, Daniel P., Nasto, Luigi A., St Croix, Claudette M., Usas, Arvydas, Vo, Nam, Huard, Johnny, Clemens, Paula R., Stolz, Donna B., Guttridge, Denis C., Watkins, Simon C., Garinis, George A., Wang, Yinsheng, Niedernhofer, Laura J., Robbins, Paul D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386805/
https://ncbi.nlm.nih.gov/pubmed/22706308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45785
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi