NF-κB inhibition delays DNA damage–induced senescence and aging in mice

The accumulation of cellular damage, including DNA damage, is thought to contribute to aging-related degenerative changes, but how damage drives aging is unknown. XFE progeroid syndrome is a disease of accelerated aging caused by a defect in DNA repair. NF-κB, a transcription factor activated by cel...

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Detalhes bibliográficos
Main Authors: Tilstra, Jeremy S., Robinson, Andria R., Wang, Jin, Gregg, Siobhán Q., Clauson, Cheryl L., Reay, Daniel P., Nasto, Luigi A., St Croix, Claudette M., Usas, Arvydas, Vo, Nam, Huard, Johnny, Clemens, Paula R., Stolz, Donna B., Guttridge, Denis C., Watkins, Simon C., Garinis, George A., Wang, Yinsheng, Niedernhofer, Laura J., Robbins, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386805/
https://ncbi.nlm.nih.gov/pubmed/22706308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45785
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