Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

In neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and prion diseases, deposits of aggregated disease-specific proteins are found. Oligomeric aggregates are presumed to be the key neurotoxic agent. Here we describe the novel oligomer modulator anle138b [3-(1,3-b...

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Auteurs principaux: Wagner, Jens, Ryazanov, Sergey, Leonov, Andrei, Levin, Johannes, Shi, Song, Schmidt, Felix, Prix, Catharina, Pan-Montojo, Francisco, Bertsch, Uwe, Mitteregger-Kretzschmar, Gerda, Geissen, Markus, Eiden, Martin, Leidel, Fabienne, Hirschberger, Thomas, Deeg, Andreas A., Krauth, Julian J., Zinth, Wolfgang, Tavan, Paul, Pilger, Jens, Zweckstetter, Markus, Frank, Tobias, Bähr, Mathias, Weishaupt, Jochen H., Uhr, Manfred, Urlaub, Henning, Teichmann, Ulrike, Samwer, Matthias, Bötzel, Kai, Groschup, Martin, Kretzschmar, Hans, Griesinger, Christian, Giese, Armin
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2013
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661926/
https://ncbi.nlm.nih.gov/pubmed/23604588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1114-9
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