Genetic Variation in 15-Hydroxyprostaglandin Dehydrogenase and Colon Cancer Susceptibility

BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE(2)) and other prostanoids. Recent studies have established the 15-PGDH gene as a colon cancer suppressor. METHODS: We evaluated 15...

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Autores principales: Thompson, Cheryl L., Fink, Stephen P., Lutterbaugh, James D., Elston, Robert C., Veigl, Martina L., Markowitz, Sanford D., Li, Li
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661460/
https://ncbi.nlm.nih.gov/pubmed/23717544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064122
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