ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells

Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) that infiltrate primary breast tumors impair patient survival. The ICOS-mediated interaction between tumor-infiltrating CD4(+) T cells and pDCs leads to the amplification of Tregs and interleukin-10 secretion. Importantly, ICOS(+) ce...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Faget, Julien, Sisirak, Vanja, Blay, Jean-Yves, Caux, Christophe, Bendriss-Vermare, Nathalie, Ménétrier-Caux, Christine
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2013
Предметы:
Author's View
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661154/
https://ncbi.nlm.nih.gov/pubmed/23802069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23185
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы