ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells

Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) that infiltrate primary breast tumors impair patient survival. The ICOS-mediated interaction between tumor-infiltrating CD4(+) T cells and pDCs leads to the amplification of Tregs and interleukin-10 secretion. Importantly, ICOS(+) ce...

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Autors principals: Faget, Julien, Sisirak, Vanja, Blay, Jean-Yves, Caux, Christophe, Bendriss-Vermare, Nathalie, Ménétrier-Caux, Christine
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661154/
https://ncbi.nlm.nih.gov/pubmed/23802069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23185
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