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Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients

The accumulation of plasmacytoid dendritic cells (pDCs) within breast carcinoma lesions is associated with a poor clinical outcome. We demonstrated that the deleterious impact of tumor-associated pDCs (TApDCs) is due to their impaired capacity to produce Type I interferon, which in turn potentiates...

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Autori principali: Sisirak, Vanja, Faget, Julien, Vey, Nelly, Blay, Jean-Yves, Ménétrier-Caux, Christine, Caux, Christophe, Bendriss-Vermare, Nathalie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583914/
https://ncbi.nlm.nih.gov/pubmed/23482834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.22338
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