BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptors in endosomes. Here, we show that BAD-LAMP (LAMP5) controls TLR9 trafficking to LAMP1(+) l...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Combes, Alexis, Camosseto, Voahirana, N’Guessan, Prudence, Argüello, Rafael J., Mussard, Julie, Caux, Christophe, Bendriss-Vermare, Nathalie, Pierre, Philippe, Gatti, Evelina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640662/
https://ncbi.nlm.nih.gov/pubmed/29030552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00695-1
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