Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1

PURPOSE: The narrow therapeutic index and large interpatient variability in sirolimus pharmacokinetics (PK) make therapeutic drug monitoring necessary. Factors responsible for PK variability are not well understood, and published PK studies do not include pediatric patients with neurofibromatosis ty...

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Detaylı Bibliyografya
Asıl Yazarlar: Scott, Jeffrey R., Courter, Joshua D., Saldaña, Shannon N., Widemann, Brigitte C., Fisher, Michael, Weiss, Brian, Perentesis, John, Vinks, Alexander A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660960/
https://ncbi.nlm.nih.gov/pubmed/23666574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0b013e318286dd3f
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