Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1

PURPOSE: The narrow therapeutic index and large interpatient variability in sirolimus pharmacokinetics (PK) make therapeutic drug monitoring necessary. Factors responsible for PK variability are not well understood, and published PK studies do not include pediatric patients with neurofibromatosis ty...

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Main Authors: Scott, Jeffrey R., Courter, Joshua D., Saldaña, Shannon N., Widemann, Brigitte C., Fisher, Michael, Weiss, Brian, Perentesis, John, Vinks, Alexander A.
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660960/
https://ncbi.nlm.nih.gov/pubmed/23666574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0b013e318286dd3f
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