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Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1
PURPOSE: The narrow therapeutic index and large interpatient variability in sirolimus pharmacokinetics (PK) make therapeutic drug monitoring necessary. Factors responsible for PK variability are not well understood, and published PK studies do not include pediatric patients with neurofibromatosis ty...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3660960/ https://ncbi.nlm.nih.gov/pubmed/23666574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0b013e318286dd3f |
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