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Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel
Pore-blocking toxins inhibit voltage-dependent K(+) channels (K(v) channels) by plugging the ion-conduction pathway. We have solved the crystal structure of paddle chimera, a K(v) channel in complex with charybdotoxin (CTX), a pore-blocking toxin. The toxin binds to the extracellular pore entryway w...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3660741/ https://ncbi.nlm.nih.gov/pubmed/23705070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00594 |
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