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Missense Variants of Uncertain Significance (VUS) Altering the Phosphorylation Patterns of BRCA1 and BRCA2

Mutations in BRCA1 and BRCA2 are responsible for a large proportion of breast-ovarian cancer families. Protein-truncating mutations have been effectively used in the clinical management of familial breast cancer due to their deleterious impact on protein function. However, the majority of missense v...

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Bibliografski detalji
Glavni autori: Tram, Eric, Savas, Sevtap, Ozcelik, Hilmi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660339/
https://ncbi.nlm.nih.gov/pubmed/23704879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062468
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