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A Guide for Functional Analysis of BRCA1 Variants of Uncertain Significance (VUS)
Germline mutations in the tumor suppressor gene BRCA1 confer an estimated lifetime risk of 56–80% for breast cancer and 15–60% for ovarian cancer. Since the mid 1990’s when BRCA1 was identified, genetic testing has revealed over 3,000 unique germline variants. However, for a significant number of th...
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| Autors principals: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3470782/ https://ncbi.nlm.nih.gov/pubmed/22753008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22150 |
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