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Telomere-Homologous G-Rich Oligonucleotides Sensitize Human Ovarian Cancer Cells to TRAIL-Induced Growth Inhibition and Apoptosis

G-rich T-oligos (GT-oligos; oligonucleotides with homology to telomeres) elicit a DNA damage response in cells and induce cytotoxic effects in certain tumor cell lines. We have previously shown that GT-oligo inhibits growth, arrests cell cycle, and induces apoptosis in ovarian, pancreatic, and prost...

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Detalhes bibliográficos
Main Authors: Sarkar, Sibaji, Faller, Douglas V.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660071/
https://ncbi.nlm.nih.gov/pubmed/23634944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2012.0401
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