Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: Mechanism and therapeutic potential

Human B- or T-cell lymphoma lines and primary murine lymphomas were treated with DNA oligonucleotides homologous to the telomere (TTAGGG repeat; “T-oligo”), either alone or in combination with standard, widely-used anticancer chemotherapeutic agents. T-oligo induces cell cycle arrest and apoptosis i...

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Autori principali: Longe, Harold O., Romesser, Paul B., Rankin, Andrew M., Faller, Douglas V., Eller, Mark S., Gilchrest, Barbara A., Denis, Gerald V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888476/
https://ncbi.nlm.nih.gov/pubmed/19003960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23946
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