Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response

The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, MEK1, DUSP5, PP2A, PIK3CA, PIK3R1, PIK3R4, PIK3R5, IRS4, AKT, NFKB1, MTOR, PTE...

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Bibliografiske detaljer
Main Authors: McCubrey, James A., Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Montalto, Giuseppe, Cervello, Melchiorre, Nicoletti, Ferdinando, Fagone, Paolo, Malaponte, Grazia, Mazzarino, Maria C., Candido, Saverio, Libra, Massimo, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Cocco, Lucio, Evangelisti, Camilla, Chiarini, Francesca, Martelli, Alberto M.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2012
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Reviews
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660063/
https://ncbi.nlm.nih.gov/pubmed/23006971
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