Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo

The potent inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE(2) biosynthesis, is an attract...

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Autors principals: Kats, Anna, Båge, Tove, Georgsson, Pierre, Jönsson, Jörgen, Quezada, Hernán Concha, Gustafsson, Anders, Jansson, Leif, Lindberg, Claes, Näsström, Karin, Yucel-Lindberg, Tülay
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2013
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659347/
https://ncbi.nlm.nih.gov/pubmed/23447581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-214445
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