Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo

The potent inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE(2) biosynthesis, is an attract...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Kats, Anna, Båge, Tove, Georgsson, Pierre, Jönsson, Jörgen, Quezada, Hernán Concha, Gustafsson, Anders, Jansson, Leif, Lindberg, Claes, Näsström, Karin, Yucel-Lindberg, Tülay
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Federation of American Societies for Experimental Biology 2013
Θέματα:
Research Communications
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659347/
https://ncbi.nlm.nih.gov/pubmed/23447581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-214445
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