Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo

The potent inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE(2) biosynthesis, is an attract...

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Bibliografiske detaljer
Main Authors: Kats, Anna, Båge, Tove, Georgsson, Pierre, Jönsson, Jörgen, Quezada, Hernán Concha, Gustafsson, Anders, Jansson, Leif, Lindberg, Claes, Näsström, Karin, Yucel-Lindberg, Tülay
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2013
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659347/
https://ncbi.nlm.nih.gov/pubmed/23447581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-214445
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