Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo

The potent inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE(2) biosynthesis, is an attract...

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Detalhes bibliográficos
Main Authors: Kats, Anna, Båge, Tove, Georgsson, Pierre, Jönsson, Jörgen, Quezada, Hernán Concha, Gustafsson, Anders, Jansson, Leif, Lindberg, Claes, Näsström, Karin, Yucel-Lindberg, Tülay
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659347/
https://ncbi.nlm.nih.gov/pubmed/23447581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-214445
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