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RNA toxicity in polyglutamine disorders: concepts, models, and progress of research
In Huntington's disease and other polyglutamine (polyQ) disorders, mutant proteins containing a long polyQ stretch are well documented as the trigger of numerous aberrant cellular processes that primarily lead to degeneration and, ultimately, the death of neuronal cells. However, mutant transcr...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer-Verlag
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3659269/ https://ncbi.nlm.nih.gov/pubmed/23512265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-013-1016-2 |
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