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A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts
We performed global gene expression analyses in mouse hearts with progressive respiratory chain deficiency and found a metabolic switch at an early disease stage. The tissue-specific mitochondrial transcription factor A (Tfam) knockout mice of this study displayed a progressive heart phenotype with...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC365756/ https://ncbi.nlm.nih.gov/pubmed/14978272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308710100 |
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