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Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

Mitochondrial dysfunction is heavily implicated in Parkinson disease (PD) as exemplified by the finding of an increased frequency of respiratory chain-deficient dopamine (DA) neurons in affected patients. An inherited form of PD is caused by impaired function of Parkin, an E3 ubiquitin ligase report...

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Autori principali: Sterky, Fredrik H., Lee, Seungmin, Wibom, Rolf, Olson, Lars, Larsson, Nils-Göran
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150929/
https://ncbi.nlm.nih.gov/pubmed/21768369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103295108
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