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Age-associated mosaic respiratory chain deficiency causes trans-neuronal degeneration
Heteroplasmic mitochondrial DNA (mtDNA) mutations (mutations present only in a subset of cellular mtDNA copies) arise de novo during the normal ageing process or may be maternally inherited in pedigrees with mitochondrial disease syndromes. A pathogenic mtDNA mutation causes respiratory chain defici...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2367695/ https://ncbi.nlm.nih.gov/pubmed/18245781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn030 |
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