SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity

We have created P1 artificial chromosome transgenic mice expressing the human mitochondrial superoxide dismutase 2 (SOD2) and thus generated mice with a physiologically controlled augmentation of SOD2 expression leading to increased SOD2 enzyme activities and lowered superoxide levels. In the transg...

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Bibliografiske detaljer
Main Authors: Silva, José P, Shabalina, Irina G, Dufour, Eric, Petrovic, Natasa, Backlund, Emma C, Hultenby, Kjell, Wibom, Rolf, Nedergaard, Jan, Cannon, Barbara, Larsson, Nils-Göran
Format: Artigo
Sprog:Inglês
Udgivet: 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356306/
https://ncbi.nlm.nih.gov/pubmed/16281056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600866
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