Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene

Several mouse models have already proved valuable for investigating hypertrophic responses to cardiac stress. Here, we characterize one caused by a well defined single copy transgene, RenTgMK, that genetically clamps plasma renin and thence angiotensin II at high levels. All of the transgenic males...

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Autors principals: Caron, Kathleen M. I., James, Leighton R., Kim, Hyung-Suk, Knowles, Josh, Uhlir, Rick, Mao, Lan, Hagaman, John R., Cascio, Wayne, Rockman, Howard, Smithies, Oliver
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC365751/
https://ncbi.nlm.nih.gov/pubmed/14978280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307333101
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