Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene

Several mouse models have already proved valuable for investigating hypertrophic responses to cardiac stress. Here, we characterize one caused by a well defined single copy transgene, RenTgMK, that genetically clamps plasma renin and thence angiotensin II at high levels. All of the transgenic males...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Caron, Kathleen M. I., James, Leighton R., Kim, Hyung-Suk, Knowles, Josh, Uhlir, Rick, Mao, Lan, Hagaman, John R., Cascio, Wayne, Rockman, Howard, Smithies, Oliver
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2004
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365751/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14978280/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307333101
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