Crystal structure of the complex between thrombin and the central “E” region of fibrin

Nonsubstrate interactions of thrombin with fibrin play an important role in modulating its procoagulant activity. To establish the structural basis for these interactions, we crystallized d-Phe-Pro-Arg-chloromethyl ketone-inhibited human thrombin in complex with a fragment, E(ht), corresponding to t...

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Detaylı Bibliyografya
Asıl Yazarlar: Pechik, Igor, Madrazo, Joel, Mosesson, Michael W., Hernandez, Irene, Gilliland, Gary L., Medved, Leonid
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC365687/
https://ncbi.nlm.nih.gov/pubmed/14978285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0303440101
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