A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides
A blood clot is a meshwork of fibrin fibers built up by the systematic assembly of fibrinogen molecules proteolyzed by thrombin. Here, we describe a model of how the assembly process occurs. Five kinds of interaction are explicitly defined, including two different knob–hole interactions, an end-to-e...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18887/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11121023/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.26.14156 |
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