A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides

A blood clot is a meshwork of fibrin fibers built up by the systematic assembly of fibrinogen molecules proteolyzed by thrombin. Here, we describe a model of how the assembly process occurs. Five kinds of interaction are explicitly defined, including two different knob–hole interactions, an end-to-e...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Yang, Zhe, Mochalkin, Igor, Doolittle, Russell F.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 2000
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18887/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11121023/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.26.14156
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