STRUCTURAL BASIS FOR SEQUENTIAL CLEAVAGE OF FIBRINOPEPTIDES UPON FIBRIN ASSEMBLY

Non-substrate interaction of thrombin with fibrinogen promotes sequential cleavage of fibrinopeptides A and B (fpA and fpB) from the latter resulting in its conversion into fibrin. The recently established crystal structure of human thrombin in complex with the central part of human fibrin clarified...

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Main Authors: Pechik, Igor, Yakovlev, Sergiy, Mosesson, Michael W., Gilliland, Gary L., Medved, Leonid
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531209/
https://ncbi.nlm.nih.gov/pubmed/16533041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0525369
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