Crystal structure of the complex between thrombin and the central “E” region of fibrin

Nonsubstrate interactions of thrombin with fibrin play an important role in modulating its procoagulant activity. To establish the structural basis for these interactions, we crystallized d-Phe-Pro-Arg-chloromethyl ketone-inhibited human thrombin in complex with a fragment, E(ht), corresponding to t...

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Библиографические подробности
Главные авторы: Pechik, Igor, Madrazo, Joel, Mosesson, Michael W., Hernandez, Irene, Gilliland, Gary L., Medved, Leonid
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC365687/
https://ncbi.nlm.nih.gov/pubmed/14978285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0303440101
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