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Crystal structure of the complex between thrombin and the central “E” region of fibrin

Nonsubstrate interactions of thrombin with fibrin play an important role in modulating its procoagulant activity. To establish the structural basis for these interactions, we crystallized d-Phe-Pro-Arg-chloromethyl ketone-inhibited human thrombin in complex with a fragment, E(ht), corresponding to t...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Pechik, Igor, Madrazo, Joel, Mosesson, Michael W., Hernandez, Irene, Gilliland, Gary L., Medved, Leonid
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2004
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC365687/
https://ncbi.nlm.nih.gov/pubmed/14978285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0303440101
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