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Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.
Compared with normal erbB-2 gp185, mutant erbB-2 proteins generated by mutations either in the transmembrane domain or by NH2-terminal deletion are able to transform NIH 3T3 cells at a 10- to 100-fold greater efficiency. Mutant proteins of both classes show increased tyrosine kinase activity, sugges...
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| Publicado en: | Mol Cell Biol |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
1988
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2907606/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.12.5570 |
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