Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

Compared with normal erbB-2 gp185, mutant erbB-2 proteins generated by mutations either in the transmembrane domain or by NH2-terminal deletion are able to transform NIH 3T3 cells at a 10- to 100-fold greater efficiency. Mutant proteins of both classes show increased tyrosine kinase activity, sugges...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Segatto, O, King, C R, Pierce, J H, Di Fiore, P P, Aaronson, S A
Формат: Artigo
Язык:Inglês
Опубликовано: 1988
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC365664/
https://ncbi.nlm.nih.gov/pubmed/2907606
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы