Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

Compared with normal erbB-2 gp185, mutant erbB-2 proteins generated by mutations either in the transmembrane domain or by NH2-terminal deletion are able to transform NIH 3T3 cells at a 10- to 100-fold greater efficiency. Mutant proteins of both classes show increased tyrosine kinase activity, sugges...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Segatto, O, King, C R, Pierce, J H, Di Fiore, P P, Aaronson, S A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2907606/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.12.5570-5574.1988
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