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Peptide G-Protein-Coupled Receptors and ErbB Receptor Tyrosine Kinases in Cancer

The ErbB RTKs (EGFR, HER2, HER3, and HER4) have been well-studied in cancer. EGFR, HER2, and HER3 stimulate cancer proliferation, principally by activating the phosphatidylinositol-3-kinase and extracellular signal-regulated kinase (ERK) pathways, resulting in increased cancer cell survival and prol...

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Principais autores: Terry W. Moody, Irene Ramos-Alvarez, Robert T. Jensen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-07-01
coleção:Biology
Assuntos:
G-protein-coupled receptor
receptor tyrosine kinases
transactivation
tyrosine kinase inhibitors
monoclonal antibodies
cancer
Acesso em linha:https://www.mdpi.com/2079-7737/12/7/957
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