Prognostic impact and targeting of CRM1 in acute myeloid leukemia

Chromosomal region maintenance 1 (CRM1) is a nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal. CRM1 is involved in nuclear export of tumor suppressors such as p53. We investigated the prognostic significance of CRM1 in acute myeloid leukemia (AML) and effects...

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Hlavní autoři: Kojima, Kensuke, Kornblau, Steven M., Ruvolo, Vivian, Dilip, Archana, Duvvuri, Seshagiri, Davis, R. Eric, Zhang, Min, Wang, Zhiqiang, Coombes, Kevin R., Zhang, Nianxiang, Qiu, Yi Hua, Burks, Jared K., Kantarjian, Hagop, Shacham, Sharon, Kauffman, Michael, Andreeff, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656451/
https://ncbi.nlm.nih.gov/pubmed/23564911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-447581
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