Prognostic impact and targeting of CRM1 in acute myeloid leukemia

Chromosomal region maintenance 1 (CRM1) is a nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal. CRM1 is involved in nuclear export of tumor suppressors such as p53. We investigated the prognostic significance of CRM1 in acute myeloid leukemia (AML) and effects...

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Main Authors: Kojima, Kensuke, Kornblau, Steven M., Ruvolo, Vivian, Dilip, Archana, Duvvuri, Seshagiri, Davis, R. Eric, Zhang, Min, Wang, Zhiqiang, Coombes, Kevin R., Zhang, Nianxiang, Qiu, Yi Hua, Burks, Jared K., Kantarjian, Hagop, Shacham, Sharon, Kauffman, Michael, Andreeff, Michael
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2013
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656451/
https://ncbi.nlm.nih.gov/pubmed/23564911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-447581
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