IL-4Rα on CD4(+) T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates

RSV is the major cause of severe bronchiolitis in infants, and severe bronchiolitis as a result of RSV is associated with subsequent asthma development. A biased Th2 immune response is thought to be responsible for neonatal RSV pathogenesis; however, molecular mechanisms remain elusive. Our data dem...

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Detalhes bibliográficos
Main Authors: You, Dahui, Marr, Nico, Saravia, Jordy, Shrestha, Bishwas, Lee, Greg I., Turvey, Stuart E., Brombacher, Frank, Herbert, De'Broski R., Cormier, Stephania A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2013
Assuntos:
Host Defense & Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656337/
https://ncbi.nlm.nih.gov/pubmed/23543769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1012498
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