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The p97–UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP
The assembly and disassembly of ribonucleoproteins (RNPs) are dynamic processes that control every step of RNA metabolism, including mRNA stability. However, our knowledge of how RNP remodeling is achieved is largely limited to RNA helicase functions. Here, we report a previously unknown mechanism t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3656322/ https://ncbi.nlm.nih.gov/pubmed/23618873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.215681.113 |
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