Destabilization of Nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fiber formation

HuR promotes myogenesis by stabilizing the MyoD, Myogenin and p21 mRNAs during the fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA destabilizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle promoter nucleophosmin (NPM)...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Cammas, Anne, Sanchez, Brenda Janice, Lian, Xian Jin, Dormoy-Raclet, Virginie, van der Giessen, Kate, de Silanes, Isabel López, Ma, Jennifer, Wilusz, Carol, Richardson, John, Gorospe, Myriam, Millevoi, Stefania, Giovarelli, Matteo, Gherzi, Roberto, Di Marco, Sergio, Gallouzi, Imed-Eddine
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074165/
https://ncbi.nlm.nih.gov/pubmed/24969639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5190
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados