The retinoblastoma protein induces apoptosis directly at the mitochondria

The retinoblastoma protein gene RB-1 is mutated in one-third of human tumors. Its protein product, pRB (retinoblastoma protein), functions as a transcriptional coregulator in many fundamental cellular processes. Here, we report a nonnuclear role for pRB in apoptosis induction via pRB's direct p...

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Detaylı Bibliyografya
Asıl Yazarlar: Hilgendorf, Keren I., Leshchiner, Elizaveta S., Nedelcu, Simona, Maynard, Mindy A., Calo, Eliezer, Ianari, Alessandra, Walensky, Loren D., Lees, Jacqueline A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2013
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656319/
https://ncbi.nlm.nih.gov/pubmed/23618872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.211326.112
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