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Pro-apoptotic function of the retinoblastoma tumor suppressor protein
The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing the E2F transcription factors. This inhibition is relieved through mitogen-induced phosphorylation of pRB, triggering E2F release and activation of cell cycle genes. E2F1 can also activate pro-apoptotic genes i...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880703/ https://ncbi.nlm.nih.gov/pubmed/19249677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.01.026 |
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