Pro-apoptotic function of the retinoblastoma tumor suppressor protein

The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing the E2F transcription factors. This inhibition is relieved through mitogen-induced phosphorylation of pRB, triggering E2F release and activation of cell cycle genes. E2F1 can also activate pro-apoptotic genes i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ianari, Alessandra, Natale, Tiziana, Calo, Eliezer, Ferretti, Elisabetta, Alesse, Edoardo, Screpanti, Isabella, Haigis, Kevin, Gulino, Alberto, Lees, Jacqueline A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880703/
https://ncbi.nlm.nih.gov/pubmed/19249677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.01.026
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