Plekhg4 Is a Novel Dbl Family Guanine Nucleotide Exchange Factor Protein for Rho Family GTPases

Mutations in the PLEKHG4 (puratrophin-1) gene are associated with the heritable neurological disorder autosomal dominant spinocerebellar ataxia. However, the biochemical functions of this gene product have not been described. We report here that expression of Plekhg4 in the murine brain is developme...

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Bibliografiske detaljer
Main Authors: Gupta, Meghana, Kamynina, Elena, Morley, Samantha, Chung, Stacey, Muakkassa, Nora, Wang, Hong, Brathwaite, Shayna, Sharma, Gaurav, Manor, Danny
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656306/
https://ncbi.nlm.nih.gov/pubmed/23572525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.430371
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