Targeting Stat3 and Smad7 to restore TGF-β cytostatic regulation of tumor cells in vitro and in vivo

Transforming Growth Factor-β (TGF-β) and Epidermal Growth Factor (EGF) signaling pathways are both independently implicated as key regulators in tumor formation and progression. Here, we report that the tumor-associated overexpression of epidermal growth factor receptor (EGFR) desensitizes TGF-β sig...

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Detalhes bibliográficos
Main Authors: Luwor, R B, Baradaran, B, Taylor, L E, Iaria, J, Nheu, T V, Amiry, N, Hovens, C M, Wang, B, Kaye, A H, Zhu, H-J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655378/
https://ncbi.nlm.nih.gov/pubmed/22751114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.260
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