The Smad7–Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-β

In most human cancers the Myc proto-oncogene is highly activated. Dysregulation of Myc oncoprotein contributes to tumorigenesis in numerous tissues and organs. Thus, targeting Myc stability could be a crucial step for cancer therapy. Here we report Smad7 as a key molecule regulating Myc stability an...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, Tae-Aug, Kang, Jin Muk, Hyun, Ja-Shil, Lee, Bona, Kim, Staci Jakyong, Yang, Eun-Sung, Hong, Suntaek, Lee, Ho-Jae, Fujii, Makiko, Niederhuber, John E., Kim, Seong-Jin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889399/
https://ncbi.nlm.nih.gov/pubmed/24259667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.136028
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