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The Smad7–Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-β
In most human cancers the Myc proto-oncogene is highly activated. Dysregulation of Myc oncoprotein contributes to tumorigenesis in numerous tissues and organs. Thus, targeting Myc stability could be a crucial step for cancer therapy. Here we report Smad7 as a key molecule regulating Myc stability an...
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| Asıl Yazarlar: | , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Company of Biologists
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3889399/ https://ncbi.nlm.nih.gov/pubmed/24259667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.136028 |
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